Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 3/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RORB | Q92753 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405229 | 0.88 | CNR1 (0.49) | CNR1THRATHRBSMN1; SMN2HTR2C | |
| SCHEMBL3405774 | 0.87 | CNR1 (0.47) | CNR1RORCTHRATHRBSMN1; SMN2 | |
| SCHEMBL3399579 | 0.85 | CNR1 (0.47) | CNR1THRATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL3402380 | 0.84 | THRA (0.45) | CNR1THRATHRBDHODHALDH1A1 | |
| SCHEMBL3403012 | 0.84 | ALDH1A1 (0.56) | CNR1ALDH1A1SMN1; SMN2HTR2CNPC1 | |
| SCHEMBL3401061 | 0.83 | RORC (0.47) | CNR1RORCALDH1A1SMN1; SMN2HTR2C | |
| SCHEMBL3402418 | 0.82 | ALDH1A1 (0.63) | CNR1THRATHRBALDH1A1SMN1; SMN2 | |
| SCHEMBL3398823 | 0.82 | ALDH1A1 (0.47) | CNR1RORCTHRATHRBALDH1A1 | |
| SCHEMBL3398373 | 0.82 | CNR1 (0.49) | CNR1THRATHRBSMN1; SMN2HTR2C | |
| SCHEMBL3400910 | 0.81 | THRA (0.48) | CNR1THRATHRBHTR2CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |