Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 16/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 16/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4226517 | 0.83 | SLC2A1 (0.39) | — | |
| SCHEMBL3646080 | 0.82 | MTNR1A (0.42) | MTNR1AMTNR1BPTGS2HTR2CPOLB | |
| SCHEMBL3213703 | 0.78 | PTGS2 (0.38) | MTNR1AMTNR1BPTGS2HTR2CPOLB | |
| SCHEMBL3158506 | 0.75 | PTGS2 (0.54) | MTNR1AMTNR1BPTGS2HTR2CPOLB | |
| SCHEMBL1711837 | 0.74 | PTGS2 (0.55) | MTNR1AMTNR1BPTGS2HTR2C | |
| SCHEMBL2768637 | 0.73 | KCNH2 (0.36) | MTNR1AMTNR1BPOLBTDP1 | |
| SCHEMBL7492208 | 0.72 | CES2 (0.39) | — | |
| SCHEMBL6981722 | 0.71 | L3MBTL1 (0.44) | — | |
| SCHEMBL3411853 | 0.70 | KDM1A (0.43) | — | |
| SCHEMBL20562550 | 0.70 | MTNR1A (0.51) | MTNR1AMTNR1BPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-B1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LTD (GB) | 2010-11-03 | — | — | EP | disclosed |
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |
| EP-1980251-A1 | Pyrrolo[3,2,1-ij]quinoline-4-one derivatives for treating tuberculosis | GLAXO GROUP LIMITED (GB) | 2008-10-15 | — | — | EP | disclosed |