Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405410 | 0.99 | HPGD (0.47) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3400521 | 0.94 | GAA (0.45) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL13309646 | 0.91 | HPGD (0.47) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3400541 | 0.85 | HPGD (0.48) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3405815 | 0.85 | MAPT (0.52) | HPGDNPC1MAPTSMYD2 | |
| SCHEMBL3402209 | 0.84 | ACKR3 (0.52) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3404196 | 0.84 | ALDH1A1 (0.60) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3402848 | 0.83 | LMNA (0.52) | NPC1MAPT | |
| SCHEMBL3399919 | 0.83 | HPGD (0.46) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 | |
| SCHEMBL3429158 | 0.83 | GLA (0.51) | HPGDNPC1CHRM4SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |