Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13102471 | 0.83 | L3MBTL1 (0.48) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL12574371 | 0.83 | SMN1; SMN2 (0.62) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL3407850 | 0.83 | ALDH1A1 (0.67) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL537132 | 0.82 | NPC1 (0.51) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL4347123 | 0.78 | RAB9A (0.68) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1925940 | 0.78 | HDAC1 (0.56) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL1927069 | 0.75 | NPC1 (0.51) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL13483905 | 0.74 | L3MBTL1 (0.71) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL16644055 | 0.73 | NPC1 (0.64) | NPC1RAB9AHPGDSMN1; SMN2L3MBTL1 | |
| SCHEMBL25841169 | 0.70 | LMNA (0.65) | LMNANPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130237507-A1 | Novel Amide Compounds | ASTRAZENECA AB INTELLECTUAL PROPERTY (GB) | 2013-09-12 | — | — | US | disclosed |
| US-20100256104-A1 | NOVEL AMIDE COMPOUNDS | ASTRAZENECA R&D (SE) | 2010-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256104-A1 | NOVEL AMIDE COMPOUNDS | H1-4, H1-3, H1-5 | LMNA 1928/4885NPC1 2071/4885RAB9A 1171/4885 |
| US-20130237507-A1 | Novel Amide Compounds | H1-4, H1-3, H1-5 | LMNA 2298/4885NPC1 1980/4885RAB9A 1163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.