Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGER | Q15109 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406028 | 0.94 | GLA (0.50) | AGERHRH3MAPTALDH1A1NPC1 | |
| SCHEMBL3404897 | 0.89 | ACHE (0.54) | ACHEMAPTALDH1A1CHRM4TP53 | |
| SCHEMBL3399687 | 0.87 | CHRM4 (0.52) | ACHEHRH3MAPTALDH1A1NPC1 | |
| SCHEMBL3405206 | 0.86 | GLA (0.60) | MAPTALDH1A1NPC1HPGDCHRM4 | |
| SCHEMBL3403571 | 0.85 | PPARA (0.58) | ALDH1A1NPC1CHRM4 | |
| SCHEMBL3398627 | 0.85 | CHRM4 (0.60) | HRH3MAPTKDM4EALDH1A1NPC1 | |
| SCHEMBL3404512 | 0.85 | HRH3 (0.62) | HRH3KDM4ENPC1CHRM4THRB | |
| SCHEMBL3399330 | 0.84 | KCNH2 (0.51) | HRH3MAPTKCNH2NPC1HPGD | |
| SCHEMBL3401183 | 0.84 | MAPT (0.49) | ACHEMAPTKDM4EALDH1A1THRB | |
| SCHEMBL3400105 | 0.84 | HRH3 (0.53) | HRH3NPC1HPGDCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |