Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398394 | 0.93 | KDM4E (0.54) | MAPTTHRBKDM4EACHEPOLB | |
| SCHEMBL3399700 | 0.93 | KDM4E (0.56) | MAPTTHRBKDM4EACHEPOLB | |
| SCHEMBL3404897 | 0.92 | ACHE (0.54) | MAPTTHRBDRD3ACHEGAA | |
| SCHEMBL3403357 | 0.91 | DRD3 (0.49) | DRD3HTR1AHTR2AGAASMYD2 | |
| SCHEMBL3402142 | 0.86 | CD274 (0.48) | MAPTTHRBDRD3HTR1AHTR2A | |
| SCHEMBL3404939 | 0.86 | HDAC3 (0.49) | MAPTTHRBDRD3HTR1AHTR2A | |
| SCHEMBL3399682 | 0.86 | DRD2 (0.49) | MAPTTHRBDRD3HTR1AHTR2A | |
| SCHEMBL3399687 | 0.86 | CHRM4 (0.52) | MAPTACHEGAASMYD2PPARA | |
| SCHEMBL3398904 | 0.85 | POLB (0.60) | MAPTTHRBKDM4EACHEPOLB | |
| SCHEMBL3405465 | 0.85 | CHRM4 (0.47) | MAPTKDM4EGAAPOLBDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |