SCHEMBL3401294

SCHEMBL3401294

Oc1ccccc1N=C1CC=Cc2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.38
MAPT P10636 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
LMNA P02545 3/20 0.38
KDM4E B2RXH2 2/20 0.38
MEN1 O00255 2/20 0.38
HTT P42858 2/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 2/20 0.37
RAB9A P51151 2/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
TP53 P04637 1/20 0.32
MAPK1 P28482 1/20 0.32
MAPK10 P53779 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7866209 0.76 CYP2D6 (0.34) MAPTSMN1; SMN2LMNAKDM4EMEN1
SCHEMBL7866217 0.76 CYP2D6 (0.34) MAPTSMN1; SMN2LMNAKDM4EMEN1
SCHEMBL7886462 0.75 HPGD (0.40) MAPTSMN1; SMN2LMNAKDM4EMEN1
SCHEMBL7886467 0.75 HPGD (0.40) MAPTSMN1; SMN2LMNAKDM4EMEN1
SCHEMBL7069264 0.72 ALDH1A1 (0.33) MAPTLMNAKDM4EMEN1HTT
SCHEMBL7069267 0.72 ALDH1A1 (0.33) MAPTLMNAKDM4EMEN1HTT
SCHEMBL2035577 0.70 MAPT (0.41) NPC1MAPTSMN1; SMN2LMNAKDM4E
SCHEMBL1941287 0.69 ALDH1A1 (0.40) MAPTLMNAKDM4EMEN1HTT
SCHEMBL28540454 0.69 KMT2A (0.37) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL9435237 0.68 MAPT (0.32) MAPTLMNAKDM4EMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9437828-B2 Electroluminescent device using azomethine-lithium-complex as electron injection layer MERCK PATENT GMBH (DE) 2016-09-06 US disclosed
US-20150065725-A1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER MERCK PATENT GMBH (DE) 2015-03-05 US disclosed
US-8883325-B2 Electroluminescent device using azomethine-lithium-complex as electron injection layer MERCK PATENT GMBH (DE) 2014-11-11 US disclosed
US-20120205638-A1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER MERCK PATENT GMBH (DE) 2012-08-16 US disclosed
US-20100327264-A1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER MERCK PATNET GMBH (DE) 2010-12-30 US disclosed
EP-2095690-B1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER MERCK PATENT GMBH (DE) 2010-10-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120205638-A1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER ACSL3, APOL1, INTS9 NPC1 1103/4885MAPT 3539/4885SMN1; SMN2 4597/4885
US-20100327264-A1 ELECTROLUMINESCENT DEVICE USING AZOMETHINE-LITHIUM-COMPLEX AS ELECTRON INJECTION LAYER ACSL3, APOL1, INTS9 NPC1 1206/4885MAPT 3581/4885SMN1; SMN2 4607/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.