Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337234 | 0.76 | HCRTR2 (0.71) | MEN1KMT2ATHRBPTGER1ALDH1A1 | |
| SCHEMBL1632092 | 0.75 | KEAP1 (0.86) | MEN1KMT2ALMNATP53KEAP1 | |
| SCHEMBL12407352 | 0.74 | PTGER1 (0.64) | KMT2ALMNATHRBNPSR1PTGER1 | |
| SCHEMBL10144079 | 0.74 | MAPT (0.63) | MEN1KMT2ALMNATP53NPSR1 | |
| SCHEMBL14427561 | 0.74 | MCOLN3 (0.67) | MEN1KMT2ALMNATP53PTGER1 | |
| SCHEMBL24279587 | 0.74 | KEAP1 (0.65) | MEN1KMT2ALMNATP53PTGER1 | |
| SCHEMBL12407762 | 0.73 | PTGER1 (0.64) | MEN1KMT2ALMNATHRBNPSR1 | |
| SCHEMBL23711009 | 0.72 | ALDH1A1 (0.74) | MEN1KMT2ALMNATHRBPTGER1 | |
| SCHEMBL12407354 | 0.72 | PTGER1 (0.78) | THRBPTGER1SMN1; SMN2 | |
| SCHEMBL12407356 | 0.72 | PTGER1 (0.74) | MEN1KMT2ALMNATHRBPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335901-B1 | PHARMACEUTICALLY ACTIVE SULFANILIDE DERIVATIVES | MERCK SERONO SA (CH) | 2010-04-14 | — | — | EP | disclosed |
| US-7312358-B2 | Pharmaceutically active sulfanilide derivatives | LABORATOIRES SERONO SA (CH) | 2007-12-25 | — | — | US | disclosed |
| US-7312358-B2 | Pharmaceutically active sulfanilide derivatives | LABORATOIRES SERONO SA (CH) | 2007-12-25 | — | — | US | disclosed |
| US-7312358-B2 | Pharmaceutically active sulfanilide derivatives | LABORATOIRES SERONO SA (CH) | 2007-12-25 | — | — | US | disclosed |