Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340407 | 0.88 | L3MBTL1 (0.46) | KMT2AMEN1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL339395 | 0.84 | ALDH1A1 (0.56) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL20195079 | 0.81 | LMNA (0.47) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL340091 | 0.74 | MEN1 (0.55) | KMT2AMEN1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL28168069 | 0.74 | ALDH1A1 (0.67) | MAPTSMN1; SMN2ALDH1A1RECQLLMNA | |
| SCHEMBL1718875 | 0.72 | CYP3A4 (0.61) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13652538 | 0.72 | LMNA (0.70) | KMT2AMEN1SMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5171029 | 0.72 | ABCC4 (0.52) | SMN1; SMN2ALDH1A1LMNAABCC4GAA | |
| SCHEMBL20661665 | 0.72 | ABCC4 (0.52) | MAPTSMN1; SMN2L3MBTL1ALDH1A1LMNA | |
| SCHEMBL341572 | 0.71 | LMNA (0.38) | KMT2AMEN1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104557599-B | Preparation and splitting method of 2-acyl amino-3-biphenylylpropionic acid | 浙江九洲药业股份有限公司 | 2017-02-22 | — | — | CN | disclosed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| CN-104557599-A | Preparation and splitting method of 2-acyl amino-3-biphenylylpropionic acid | ZHEJIANG JIUZHOU PHARM CO LTD | 2015-04-29 | — | — | CN | disclosed |
| CN-102482202-B | Preparation and resolution method of 2-acylamino-3-biphenylyl propionic acid | ZHEJIANG JIUZHOU PHARMACEUTICA | 2015-02-18 | — | — | CN | disclosed |
| EP-2387558-B1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2014-08-27 | — | — | EP | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-8703990-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2014-04-22 | — | — | US | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| EP-2387558-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253230-A1 | Temperature Sensitive Valve Having Shape Memory Actuator | OMNITEK PARTNERS LLC (US) | 2011-10-20 | — | — | US | disclosed |
| WO-2010081410-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | KMT2A 2149/4885MEN1 3083/4885MAPT 1676/4885 |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | KMT2A 2149/4885MEN1 3083/4885MAPT 1676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.