Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | THRA | P10827 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405569 | 0.91 | CNR1 (0.48) | KMT2AHRH3ALDH1A1MEN1MAPT | |
| SCHEMBL3402275 | 0.91 | CNR1 (0.43) | KMT2AHRH3ALDH1A1KDM4EMEN1 | |
| SCHEMBL3404063 | 0.89 | TRPM8 (0.50) | HRH3MAPTCNR1TRPM8HTR2C | |
| SCHEMBL3402239 | 0.89 | CNR1 (0.49) | KMT2AHRH3CNR1HTR2CTHRA | |
| SCHEMBL3401483 | 0.89 | RAB9A (0.49) | KMT2AHRH3ALDH1A1KDM4EMEN1 | |
| SCHEMBL3401176 | 0.89 | CNR1 (0.60) | HRH3ALDH1A1MAPTL3MBTL1CNR1 | |
| SCHEMBL3405411 | 0.88 | CNR1 (0.46) | KMT2AHRH3ALDH1A1KDM4EMEN1 | |
| SCHEMBL3402322 | 0.88 | CNR1 (0.46) | KMT2AHRH3ALDH1A1KDM4EMEN1 | |
| SCHEMBL3405885 | 0.88 | THRA (0.45) | KMT2AHRH3ALDH1A1KDM4EMEN1 | |
| SCHEMBL3405461 | 0.88 | CNR1 (0.46) | KMT2AHRH3ALDH1A1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |