Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.60 |
| ▸ | RORC | P51449 | 2/20 | 0.59 |
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL340246 | 0.89 | EPHX1 (0.64) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL23560422 | 0.87 | MTNR1B (0.57) | CNR1NPC1RAB9AALDH1A1HTT | |
| SCHEMBL9479531 | 0.86 | CASP3 (0.69) | NPC1RAB9AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14424453 | 0.83 | EPHX1 (0.72) | CASRCNR1ROCK2ROCK1NPC1 | |
| SCHEMBL11186170 | 0.83 | ROCK2 (0.64) | ROCK2ROCK1RAB9AHTTABL1 | |
| SCHEMBL14424478 | 0.82 | EPHX1 (0.80) | CASRCNR1ALDH1A1HTTEPHX1 | |
| SCHEMBL10133206 | 0.81 | ROCK2 (0.80) | CASRRORCCNR1ROCK2ROCK1 | |
| SCHEMBL5359926 | 0.81 | SMN1; SMN2 (0.77) | CNR1ROCK2PTPN1PTPN11NPC1 | |
| SCHEMBL18132370 | 0.80 | KDM4E (0.56) | PTPN1NPC1RAB9AALDH1A1HTT | |
| SCHEMBL13614142 | 0.80 | NAMPT (0.58) | NPC1RAB9AALDH1A1SMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |