Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143025 | 0.88 | ADRB2 (0.40) | STAT3ALDH1A1KDM4EHPGDTDP1 | |
| SCHEMBL143026 | 0.81 | AGTR2 (0.30) | — | |
| SCHEMBL115725 | 0.75 | ADRB2 (0.43) | STAT3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL12825630 | 0.71 | ADRB2 (0.40) | STAT3ALDH1A1KDM4EHPGDPDK1 | |
| SCHEMBL115984 | 0.71 | PDK1 (0.43) | PDK1PDK2PDK3PDK4ABCB1 | |
| SCHEMBL12825261 | 0.70 | ADRB2 (0.43) | STAT3ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL3820416 | 0.70 | TOP1 (0.44) | STAT3TOP1ALDH1A1KDM4EHPGD | |
| SCHEMBL1461785 | 0.69 | KDM4E (0.40) | STAT3TSHRTOP1ALDH1A1KDM4E | |
| SCHEMBL583954 | 0.69 | STAT3 (0.43) | STAT3TSHRMAPK1TOP1ALDH1A1 | |
| SCHEMBL10390664 | 0.69 | ABCB1 (0.41) | ALDH1A1KDM4EPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |