Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.61 |
| ▸ | HTR3B | O95264 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | HTR3A | P46098 | 2/20 | 0.61 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.61 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.61 |
| ▸ | THPO | P40225 | 1/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6192022 | 0.80 | NPC1 (0.67) | NPC1RAB9AKDM4EHTR1ALMNA | |
| SCHEMBL7695990 | 0.79 | NPC1 (0.64) | NPC1RAB9AALDH1A1KDM4EHTR3A | |
| SCHEMBL6192921 | 0.78 | HTR1A (0.67) | NPC1RAB9AHTR1ADRD2DRD3 | |
| SCHEMBL606721 | 0.77 | HRH3 (1.00) | NPC1RAB9AALDH1A1HRH3KDM4E | |
| SCHEMBL12962208 | 0.76 | NPC1 (0.61) | NPC1RAB9AKDM4EHTR1ALMNA | |
| SCHEMBL10834319 | 0.76 | HTR3A (0.62) | NPC1RAB9AALDH1A1KDM4EHTR3E | |
| SCHEMBL8011275 | 0.76 | HTR1A (1.00) | NPC1RAB9AHTR1ADRD2DRD3 | |
| SCHEMBL4317233 | 0.75 | KDM4E (0.60) | NPC1RAB9AALDH1A1HRH3KDM4E | |
| SCHEMBL5664122 | 0.74 | HRH3 (0.71) | NPC1RAB9AALDH1A1HRH3KDM4E | |
| SCHEMBL29604668 | 0.74 | HRH3 (0.71) | NPC1RAB9AALDH1A1HRH3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | NIH-DEITR | 2017-07-06 | — | — | US | claimed |
| US-9572815-B2 | Methods and compositions of p27KIP1 transcriptional modulators | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-02-21 | — | — | US | claimed |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2016-02-04 | — | — | US | claimed |
| WO-2014145205-A2 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTION MODULATORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-18 | — | — | WO | claimed |
| CN-101990433-A | Compounds that enhance atoh-1 expression | BRIGHAM & WOMENS HOSPITAL | 2011-03-23 | — | — | CN | claimed |
| EP-2254572-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | Massachusetts Eye & Ear Infirmary (US) | 2010-12-01 | — | — | EP | claimed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | claimed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | claimed |
| US-11160808-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2021-11-02 | — | — | US | disclosed |
| US-11160808-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2021-11-02 | — | — | US | disclosed |
| US-20200179394-A1 | Compounds that Enhance Atoh1 Expression | MASSACHUSETTS EYE & EAR INFIRMARY | 2020-06-11 | — | — | US | disclosed |
| US-20200179394-A1 | Compounds that Enhance Atoh1 Expression | MASSACHUSETTS EYE & EAR INFIRMARY | 2020-06-11 | — | — | US | disclosed |
| EP-2732819-B1 | Compounds that enhance Atoh-1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2019-10-16 | — | — | EP | disclosed |
| EP-2732819-B1 | Compounds that enhance Atoh-1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2019-10-16 | — | — | EP | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | WNT1, CTNNB1, CTNNBL1 | NPC1 1011/4885RAB9A 4314/4885ALDH1A1 877/4885 |
| US-20200179394-A1 | Compounds that Enhance Atoh1 Expression | DACH1, EZH1, CREBBP | NPC1 1018/4885RAB9A 3293/4885ALDH1A1 189/4885 |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | WNT1, CTNNB1, CTNNBL1 | NPC1 966/4885RAB9A 4168/4885ALDH1A1 969/4885 |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | DACH1, EZH1, CREBBP | NPC1 1018/4885RAB9A 3293/4885ALDH1A1 189/4885 |
| US-11160808-B2 | Compounds that enhance Atoh1 expression | DACH1, EZH1, CREBBP | NPC1 1018/4885RAB9A 3293/4885ALDH1A1 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.