Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | HTT | P42858 | 5/20 | 0.65 |
| ▸ | GAA | P10253 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.57 |
| ▸ | PHGDH | O43175 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.57 |
| ▸ | ARG1 | P05089 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30729340 | 1.00 | ALDH1A1 (0.65) | ALDH1A1HTTGAASMN1; SMN2NPC1 | |
| SCHEMBL6300608 | 0.84 | SMO (0.71) | HTTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL11138747 | 0.78 | TDP1 (0.67) | ALDH1A1GAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL6814980 | 0.78 | MEN1 (0.55) | ALDH1A1HTTGAASMN1; SMN2NPC1 | |
| SCHEMBL7568843 | 0.78 | MAPT (0.66) | ALDH1A1HTTGAASMN1; SMN2NPC1 | |
| SCHEMBL5179508 | 0.77 | ALDH1A1 (0.69) | ALDH1A1HTTGAASMN1; SMN2RAB9A | |
| SCHEMBL469849 | 0.76 | NOX1 (0.84) | ALDH1A1HTTGAASMN1; SMN2NPC1 | |
| SCHEMBL8373805 | 0.76 | POLB (1.00) | ALDH1A1HTTGAARAB9AKMT2A | |
| SCHEMBL8719467 | 0.76 | ALDH1A1 (0.71) | ALDH1A1HTTGAASMN1; SMN2NPC1 | |
| SCHEMBL14096418 | 0.75 | ALDH1A1 (0.81) | ALDH1A1HTTGAASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | NIH-DEITR | 2017-07-06 | — | — | US | claimed |
| US-9572815-B2 | Methods and compositions of p27KIP1 transcriptional modulators | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-02-21 | — | — | US | claimed |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2016-02-04 | — | — | US | claimed |
| WO-2014145205-A2 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTION MODULATORS | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2014-09-18 | — | — | WO | claimed |
| EP-2254572-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | Massachusetts Eye & Ear Infirmary (US) | 2010-12-01 | — | — | EP | claimed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | claimed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | claimed |
| US-12239651-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2025-03-04 | — | — | US | disclosed |
| US-12156899-B2 | Methods and compositions for regenerating hair cells and/or supporting cells | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-12-03 | — | — | US | disclosed |
| US-20240299432-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2024-09-12 | — | — | US | disclosed |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-07-23 | — | — | US | disclosed |
| US-11963968-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-04-23 | — | — | US | disclosed |
| US-20240100079-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS IN THE INNER EAR OF ADULT MAMMALS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-03-28 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188131-B2 | Compounds that enhance Atoh1 expression | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-09-17 | — | — | US | disclosed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299432-A1 | TREATMENT OF HEARING LOSS | HES1, NOTCH1, NOTCH4 | ALDH1A1 2645/4885HTT 2110/4885GAA 4549/4885 |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | HES1, NOTCH1, NOTCH2 | ALDH1A1 1081/4885HTT 2538/4885GAA 4425/4885 |
| US-20170189477-A1 | Methods and Compositions of P27KIP1 Transcriptional Modulators | WNT1, CTNNB1, CTNNBL1 | ALDH1A1 877/4885HTT 1898/4885GAA 4348/4885 |
| US-12156899-B2 | Methods and compositions for regenerating hair cells and/or supporting cells | HES1, NOTCH1, NOTCH4 | ALDH1A1 2172/4885HTT 2236/4885GAA 4768/4885 |
| US-20160030445-A1 | METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS | WNT1, CTNNB1, CTNNBL1 | ALDH1A1 969/4885HTT 1868/4885GAA 4215/4885 |
| US-20090232780-A1 | COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION | DACH1, EZH1, CREBBP | ALDH1A1 189/4885HTT 626/4885GAA 3305/4885 |
| US-12239651-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | ALDH1A1 2645/4885HTT 2110/4885GAA 4549/4885 |
| US-11963968-B2 | Treatment of hearing loss | HES1, NOTCH1, NOTCH4 | ALDH1A1 2645/4885HTT 2110/4885GAA 4549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.