Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405569 | 0.90 | CNR1 (0.48) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3405771 | 0.90 | CNR1 (0.43) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3402275 | 0.90 | CNR1 (0.43) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3401176 | 0.88 | CNR1 (0.60) | CNR1HTR2CALDH1A1HPGDCES2 | |
| SCHEMBL3397023 | 0.88 | RORC (0.42) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3402609 | 0.87 | THRA (0.47) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3401274 | 0.87 | SLC29A1 (0.47) | CNR1THRATHRBHRH3 | |
| SCHEMBL3402581 | 0.86 | CNR1 (0.47) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3402410 | 0.86 | CNR1 (0.47) | CNR1THRATHRBHTR2CALDH1A1 | |
| SCHEMBL3401483 | 0.86 | RAB9A (0.49) | CNR1ALDH1A1HRH3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |