Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.69 |
| ▸ | OPRL1 | P41146 | 15/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4631671 | 0.97 | OPRM1 (0.73) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL7478459 | 0.94 | OPRM1 (0.69) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7313869 | 0.82 | OPRM1 (0.56) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7309717 | 0.82 | OPRM1 (0.53) | OPRM1OPRL1OPRK1 | |
| SCHEMBL6543224 | 0.82 | OPRM1 (0.53) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3410403 | 0.82 | OPRM1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7514792 | 0.81 | OPRM1 (0.56) | OPRM1OPRL1OPRK1 | |
| SCHEMBL7312540 | 0.81 | OPRM1 (0.51) | OPRM1OPRL1OPRK1 | |
| Hydrochloric Acid SCHEMBL6543281 | 0.80 | OPRM1 (0.54) | OPRM1OPRL1OPRK1 | |
| SCHEMBL2834926 | 0.79 | OPRM1 (0.72) | OPRM1OPRL1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915849-A2 | PROCESS FOR THE PREPARATION OF 3,3-DISUBSTITUTED PIPERIDINES | Smithkline Beecham S.p.A. (IT) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998005640-A2 | PROCESS FOR THE PREPARATION OF 3,3-DISUBSTITUTED PIPERIDINES | SMITHKLINE BEECHAM S.P.A. (IT) | 1998-02-12 | — | — | WO | disclosed |