Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | FDPS | P14324 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4066280 | 0.83 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ALDH1A1AOC3 | |
| SCHEMBL3404257 | 0.81 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3ALDH1A1AOC3 | |
| SCHEMBL4066408 | 0.70 | SLC6A2 (0.44) | SLC6A2SLC6A4SLC6A3ALDH1A1AOC3 | |
| SCHEMBL4067931 | 0.67 | CFD (0.49) | SLC6A2SLC6A4SLC6A3AOC3KCNH2 | |
| SCHEMBL4578371 | 0.64 | AOC3 (0.44) | SLC6A2SLC6A4SLC6A3AOC3CYP2D6 | |
| SCHEMBL16334289 | 0.64 | AOC3 (0.44) | SLC6A2SLC6A4SLC6A3AOC3CYP2D6 | |
| SCHEMBL2415110 | 0.64 | AOC3 (0.44) | SLC6A2SLC6A4SLC6A3AOC3CYP2D6 | |
| Hydrochloric Acid SCHEMBL27833790 | 0.63 | IDO1 (0.45) | SLC6A2SLC6A4SLC6A3AOC3CYP2D6 | |
| Hydrochloric Acid SCHEMBL27833791 | 0.63 | IDO1 (0.45) | SLC6A2SLC6A4SLC6A3AOC3CYP2D6 | |
| SCHEMBL21798457 | 0.63 | ALDH1A1 (0.52) | ALDH1A1KMT2APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152219-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA R&D (SE) | 2010-06-17 | — | — | US | disclosed |
| US-20070142413-A1 | Pyrazole derivatives as inhibitors of receptor tyrosone kinases | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152219-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | LTK, ERBB2, ERBB3 | SLC6A2 4716/4885SLC6A4 4244/4885SLC6A3 4041/4885 |
| US-20070142413-A1 | Pyrazole derivatives as inhibitors of receptor tyrosone kinases | PRKDC, MUSK, LTK | SLC6A2 4435/4885SLC6A4 3970/4885SLC6A3 3481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.