Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2498510 | 0.89 | L3MBTL1 (0.81) | L3MBTL1SIGMAR1ATMMAPK1HTR7 | |
| Hydrochloric Acid SCHEMBL7966303 | 0.88 | L3MBTL1 (0.79) | L3MBTL1SIGMAR1ATMMAPK1HTR7 | |
| SCHEMBL1346829 | 0.86 | L3MBTL1 (0.65) | L3MBTL1SIGMAR1ALDH1A1MAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL7966700 | 0.85 | L3MBTL1 (0.63) | L3MBTL1SIGMAR1ALDH1A1MAPK1POLB | |
| SCHEMBL17374111 | 0.84 | PRMT1 (0.54) | L3MBTL1SIGMAR1HTR6ALDH1A1MAPK1 | |
| SCHEMBL17374138 | 0.83 | HTR7 (0.66) | L3MBTL1SIGMAR1ALDH1A1HTR7HTR1A | |
| SCHEMBL17373973 | 0.80 | MEN1 (0.67) | L3MBTL1HTR6ALDH1A1MEN1KMT2A | |
| SCHEMBL23682666 | 0.80 | L3MBTL1 (1.00) | L3MBTL1SIGMAR1ATMHTR6ALDH1A1 | |
| SCHEMBL23718113 | 0.78 | L3MBTL1 (0.74) | L3MBTL1SIGMAR1ATMALDH1A1MEN1 | |
| SCHEMBL3386980 | 0.77 | ATM (0.66) | L3MBTL1SIGMAR1ATMALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846687-B2 | Pyrazine compounds as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2014-09-30 | — | — | US | disclosed |
| EP-2597085-A1 | Organic compounds | Novartis AG (CH) | 2013-05-29 | — | — | EP | disclosed |
| US-8268834-B2 | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme | NOVARTIS AG (CH) | 2012-09-18 | — | — | US | disclosed |
| US-20120214800-A1 | Organic Compounds | NOVARTIS AG (CH) | 2012-08-23 | — | — | US | disclosed |
| EP-2257529-A2 | PYRIDINES AND PYRAZINES AS INHIBITORS OF PI3K | Novartis AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009115517-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-09-24 | — | — | WO | disclosed |
| US-20090239847-A1 | Organic compounds | NOVARTIS AG (CH) | 2009-09-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239847-A1 | Organic compounds | AR, TRPA1, IL33 | L3MBTL1 3906/4885SIGMAR1 293/4885ATM 2529/4885 |
| US-20120214800-A1 | Organic Compounds | AR, TRPA1, IL33 | L3MBTL1 3906/4885SIGMAR1 293/4885ATM 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.