Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP13 | P45452 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407933 | 0.84 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL16446578 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL12988370 | 0.74 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4313273 | 0.74 | MAPT (0.43) | SMN1; SMN2ALDH1A1KMT2AMAPTAR | |
| SCHEMBL8751720 | 0.74 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL6081269 | 0.73 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL28640254 | 0.73 | MEN1 (0.53) | SMN1; SMN2ALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1620272 | 0.73 | PPARG (0.56) | SMN1; SMN2ALDH1A1PPARGPPARAMAPT | |
| SCHEMBL3935722 | 0.73 | PPARG (0.56) | SMN1; SMN2ALDH1A1PPARGPPARAMAPT | |
| SCHEMBL13913371 | 0.73 | PPARG (0.56) | SMN1; SMN2ALDH1A1PPARGPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252604-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-Tech Ueno, Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009096609-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2009-08-06 | — | — | WO | disclosed |