Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10520690 | 0.88 | ALDH1A1 (0.40) | MAPTL3MBTL1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL10575629 | 0.85 | MAPT (0.44) | MAPTCRHBPCRHR2L3MBTL1LMNA | |
| SCHEMBL8371983 | 0.85 | ALDH1A1 (0.41) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11648038 | 0.85 | ALDH1A1 (0.41) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8373359 | 0.85 | ALDH1A1 (0.41) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3920080 | 0.83 | GSK3B (0.40) | MAPTLMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7262061 | 0.83 | LMNA (0.41) | MAPTLMNASMN1; SMN2TDP1KMT2A | |
| SCHEMBL11570078 | 0.81 | ALDH1A1 (0.55) | MAPTCRHBPCRHR2L3MBTL1SMN1; SMN2 | |
| SCHEMBL6795835 | 0.80 | KMT2A (0.41) | MAPTCRHBPCRHR2L3MBTL1LMNA | |
| SCHEMBL10521236 | 0.79 | ALDH1A1 (0.41) | MAPTCRHBPCRHR2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090069376-A1 | VLA-4 Antagonists | MERCK SHARP & DOHME CORP. | 2009-03-12 | — | — | US | disclosed |
| EP-1874299-A2 | VLA-4 ANTAGONISTS | Merck & Co., Inc. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006115918-A2 | VLA-4 ANTAGONISTS | MERCK & CO., INC. (US) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069376-A1 | VLA-4 Antagonists | VCAM1, SELPLG, ITGB4 | MAPT 4429/4885CRHBP 4496/4885CRHR2 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.