Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398394 | 0.86 | KDM4E (0.54) | POLBKDM4EACHECYP2D6MAPT | |
| SCHEMBL3398904 | 0.86 | POLB (0.60) | POLBKDM4ECACNA1GACHECYP2D6 | |
| SCHEMBL3399700 | 0.85 | KDM4E (0.56) | POLBKDM4ECACNA1GACHECYP2D6 | |
| SCHEMBL3404939 | 0.85 | HDAC3 (0.49) | MAPTDRD4SMYD2DRD2SMN1; SMN2 | |
| SCHEMBL3405815 | 0.84 | MAPT (0.52) | POLBKDM4ECACNA1GMAPTCYP2C9 | |
| SCHEMBL3400825 | 0.83 | CYP1A2 (0.54) | CACNA1GCYP2D6CYP2C9CYP1A2HSD17B10 | |
| SCHEMBL3399682 | 0.83 | DRD2 (0.49) | POLBKDM4EMAPTDRD4SMYD2 | |
| SCHEMBL3398788 | 0.82 | MAPT (0.48) | POLBKDM4EMAPTCYP2C9ALDH1A1 | |
| SCHEMBL3405409 | 0.81 | SCN9A (0.47) | CACNA1GCYP1A2CYP3A4CYP2C19SCN9A | |
| SCHEMBL3401355 | 0.81 | DPP4 (0.54) | KDM4ECACNA1GMAPTALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |