Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3219290 | 0.88 | PLA2G2A (0.48) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL3214978 | 0.88 | TP53 (0.47) | MAPTTSHRMAPK1HTTTLR8 | |
| SCHEMBL3218795 | 0.87 | TLR8 (0.62) | TLR8ADORA3ADORA2AADORA1ADCY10 | |
| Hydrochloric Acid SCHEMBL3208543 | 0.87 | TP53 (0.46) | MAPTTSHRMAPK1HTTTLR8 | |
| SCHEMBL4718157 | 0.87 | IDO1 (0.49) | MAPTTLR8DHFRADORA3ADORA2A | |
| SCHEMBL3196286 | 0.86 | TLR8 (0.49) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL3220931 | 0.84 | TLR8 (0.43) | GAAMAPTTSHRMAPK1HTT | |
| SCHEMBL3217251 | 0.84 | CSNK1D (0.46) | GAAMAPTTSHRTLR8DHFR | |
| SCHEMBL3205988 | 0.82 | DHFR (0.41) | TLR8DHFR | |
| SCHEMBL3214919 | 0.82 | TLR8 (0.44) | GAATSHRTLR8DHFRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2254666-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009112395-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | WO | disclosed |
| US-20090233927-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233927-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2B | GAA 1052/4885MAPT 903/4885TSHR 841/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.