Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408208 | 1.00 | TSHR (0.49) | TSHRSMN1; SMN2PSMB8PSMB5MAPT | |
| SCHEMBL6757115 | 0.78 | TSHR (0.69) | TSHRSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL7801724 | 0.78 | TSHR (0.69) | TSHRSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL24066843 | 0.68 | RIPK1 (0.42) | TSHRPOLBALDH1A1CYP2C19HPGD | |
| SCHEMBL2249845 | 0.68 | TSHR (0.67) | TSHRSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL11439195 | 0.67 | HTT (0.47) | MAPTALDH1A1HTTKDM4E | |
| SCHEMBL23135845 | 0.67 | MEN1 (0.53) | TSHRSMN1; SMN2POLBHPGDMAPK1 | |
| SCHEMBL9020652 | 0.67 | ALDH1A1 (0.40) | TSHRSMN1; SMN2MAPTPOLBALDH1A1 | |
| SCHEMBL21409442 | 0.66 | KMT2A (0.40) | TSHRMAPTALDH1A1HPGDKDM4E | |
| SCHEMBL12981697 | 0.66 | TSHR (0.42) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252575-A1 | 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Oroxcell (FR) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009112703-A1 | 2-AMINO-2-PHENYLALKANOL DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | OROXCELL (FR) | 2009-09-17 | — | — | WO | disclosed |