Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1153566 | 0.92 | KDM4E (0.46) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL1153563 | 0.92 | KDM4E (0.46) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL3404211 | 0.80 | L3MBTL1 (0.38) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL1153496 | 0.80 | — | — | |
| SCHEMBL30125106 | 0.80 | — | — | |
| SCHEMBL2752613 | 0.73 | GRM4 (0.49) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL2752612 | 0.73 | GRM4 (0.49) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL4976296 | 0.70 | ALDH1A1 (0.39) | KDM4ENPSR1MAPK1RAB9AKMT2A | |
| SCHEMBL28313608 | 0.69 | KDM4E (0.58) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL28836041 | 0.69 | L3MBTL1 (0.55) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252606-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009101078-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2009-08-20 | — | — | WO | disclosed |