Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1153563 | 1.00 | KDM4E (0.46) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL3406360 | 0.92 | KDM4E (0.41) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL3404211 | 0.87 | L3MBTL1 (0.38) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL2752613 | 0.76 | GRM4 (0.49) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL2752612 | 0.76 | GRM4 (0.49) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL4976296 | 0.76 | ALDH1A1 (0.39) | KDM4ENPSR1RAB9AKMT2AMAPK1 | |
| SCHEMBL28313608 | 0.75 | KDM4E (0.58) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL13698746 | 0.73 | L3MBTL1 (0.45) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL17113388 | 0.73 | L3MBTL1 (0.45) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 | |
| SCHEMBL31610007 | 0.73 | L3MBTL1 (0.45) | KDM4EL3MBTL1ALOX15HSP90AA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110039693-A1 | Pyrimidylmethyl Sulfonamide Compounds | BASF SE (DE) | 2011-02-17 | — | — | US | disclosed |
| WO-2009101079-A1 | PYRIMIDYLMETHYL SULFONAMIDE COMPOUNDS | BASF SE (DE) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039693-A1 | Pyrimidylmethyl Sulfonamide Compounds | TPMT, NQO2, TST | KDM4E 1251/4885L3MBTL1 4714/4885ALOX15 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.