Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CGAS | Q8N884 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 10/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PRKACA | P17612 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400978 | 0.89 | GSK3B (0.39) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL3401659 | 0.86 | GSK3B (0.39) | GSK3BCYP1A2CYP2D6 | |
| SCHEMBL4390474 | 0.81 | ALDH1A1 (0.46) | GSK3BKDM4EHTT | |
| SCHEMBL2065962 | 0.80 | KMT2A (0.46) | CGASGSK3BKDM4E | |
| SCHEMBL2065321 | 0.79 | KDM4E (0.43) | KDM4E | |
| SCHEMBL2066118 | 0.79 | ALDH1A1 (0.43) | CGASGSK3BCYP1A2 | |
| SCHEMBL2065004 | 0.79 | PRKACA (0.47) | GSK3BCDC7MAP4K4PIM1PRKACA | |
| SCHEMBL4391863 | 0.79 | MAPT (0.40) | CGASCYP2C9GSK3BCDC7MAP4K4 | |
| SCHEMBL4391283 | 0.79 | CYP2C9 (0.39) | CGASCYP2C9GSK3BCDC7MAP4K4 | |
| SCHEMBL4386108 | 0.79 | RAB9A (0.41) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957492-B1 | SUBSTITUTED BICYCLIC PYRIMIDONE DERIVATIVES | SANOFI AVENTIS (FR) | 2010-11-10 | — | — | EP | claimed |