Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4391283 | 0.89 | CYP2C9 (0.39) | ALDH1A1GAACYP2C9MEN1CYP1A2 | |
| SCHEMBL4952879 | 0.88 | MEN1 (0.47) | ALDH1A1CYP2C9MEN1CYP1A2CYP3A4 | |
| SCHEMBL4385766 | 0.87 | RAB9A (0.51) | ALDH1A1RAB9ACYP2C9MEN1CYP1A2 | |
| SCHEMBL4388471 | 0.87 | KDM4E (0.47) | ALDH1A1GAARAB9A | |
| SCHEMBL4377829 | 0.87 | ALDH1A1 (0.45) | MAPTSMN1; SMN2ALDH1A1RAB9ACYP2C9 | |
| SCHEMBL2066118 | 0.86 | ALDH1A1 (0.43) | ALDH1A1RAB9AMEN1CYP1A2CYP3A4 | |
| SCHEMBL4386498 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1RAB9ACYP2C9MEN1 | |
| SCHEMBL4383616 | 0.85 | MEN1 (0.47) | ALDH1A1GAAMEN1KMT2AACKR3 | |
| SCHEMBL4387186 | 0.83 | L3MBTL1 (0.56) | GAAMEN1KMT2A | |
| SCHEMBL4948489 | 0.83 | HSD11B1 (0.54) | ALDH1A1RAB9AMEN1KMT2ACNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | claimed |
| EP-2121635-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | Sanofi-Aventis (FR) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008078196-A2 | SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES | SANOFI-AVENTIS (FR) | 2008-07-03 | — | — | WO | disclosed |
| EP-1939187-A1 | Substituted heteroaryl pyridopyrimidone derivatives | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |