Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406823 | 0.86 | NPC1 (0.39) | IMPDH2AURKAAURKBFLT3 | |
| SCHEMBL3408862 | 0.85 | NPC1 (0.43) | ABCG2IMPDH2 | |
| SCHEMBL3410560 | 0.84 | NPC1 (0.37) | ABCG2IMPDH2CDK1 | |
| SCHEMBL3406645 | 0.83 | SMN1; SMN2 (0.37) | ABCB1ABCG2IMPDH2 | |
| SCHEMBL3409733 | 0.83 | CDK9 (0.41) | SYKRETAURKAAURKBCCNT1 | |
| SCHEMBL3409722 | 0.83 | PIK3CA (0.41) | IMPDH2JAK2 | |
| SCHEMBL3412384 | 0.82 | AGPAT2 (0.41) | CCNT1CDK9 | |
| SCHEMBL3405215 | 0.82 | KCNH2 (0.37) | IMPDH2CCNT1CDK9 | |
| SCHEMBL3412729 | 0.82 | SYK (0.40) | SYKIMPDH2PTK2CCNT1CDK9 | |
| SCHEMBL3412354 | 0.82 | PTGS2 (0.39) | SYKIMPDH2PTK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |