Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401858 | 0.83 | LMNA (0.49) | GABRG2GABRB3GABRA5KCNH2GRM5 | |
| SCHEMBL3406745 | 0.82 | GRM5 (0.50) | KCNH2GRM5 | |
| SCHEMBL10008685 | 0.82 | GAA (0.51) | POLBALDH1A1 | |
| SCHEMBL3371418 | 0.80 | CHRM1 (0.43) | PRMT5WDR77 | |
| SCHEMBL3371568 | 0.78 | GRM5 (0.41) | GRM5POLB | |
| SCHEMBL3369079 | 0.76 | HRH3 (0.40) | GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL3372611 | 0.75 | GRM5 (0.38) | PRMT5WDR77GRM5 | |
| SCHEMBL8767909 | 0.73 | L3MBTL1 (0.49) | CYP11B2PRMT5WDR77KCNH2PTGS2 | |
| SCHEMBL3369525 | 0.73 | GRM5 (0.37) | PRMT5WDR77GRM5 | |
| SCHEMBL3370941 | 0.73 | GRM5 (0.47) | GABRG2GABRB3GABRA5KCNH2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |