Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.33 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | G6PD | P11413 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407758 | 0.90 | LMNA (0.36) | KMT2AMEN1CYP46A1KDM4ECYP1A2 | |
| SCHEMBL3410082 | 0.88 | MEN1 (0.35) | KMT2AMEN1CYP46A1KDM4ECYP1A2 | |
| SCHEMBL3408377 | 0.82 | SCN9A (0.34) | KMT2AMEN1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL3410075 | 0.70 | KMT2A (0.37) | KMT2AMEN1CYP46A1KDM4ECYP1A2 | |
| SCHEMBL3406972 | 0.68 | ATR (0.37) | KMT2AMEN1CYP46A1KDM4ECYP1A2 | |
| SCHEMBL3408373 | 0.66 | HCRTR1 (0.34) | KMT2AMEN1CYP46A1KDM4ECYP1A2 | |
| SCHEMBL3406962 | 0.64 | MEN1 (0.39) | KMT2AMEN1KDM4ECYP1A2CYP2D6 | |
| SCHEMBL8174331 | 0.63 | SIRT3 (0.47) | KMT2AMEN1MKNK1CYP46A1KDM4E | |
| SCHEMBL30298688 | 0.63 | CYP46A1 (0.46) | KMT2AMEN1MKNK1MKNK2CYP46A1 | |
| SCHEMBL21465577 | 0.63 | HCRTR1 (0.37) | KMT2AMEN1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |