Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 5/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410082 | 0.85 | MEN1 (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3407758 | 0.83 | LMNA (0.36) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3406978 | 0.82 | SQOR (0.33) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3408373 | 0.69 | HCRTR1 (0.34) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3406972 | 0.65 | ATR (0.37) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3410075 | 0.65 | KMT2A (0.37) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3406962 | 0.61 | MEN1 (0.39) | MEN1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL3431023 | 0.60 | CXCR4 (0.37) | — | |
| SCHEMBL3449729 | 0.59 | CNR2 (0.45) | SCN9ASCN5AMEN1KMT2A | |
| SCHEMBL21816147 | 0.58 | ALDH1A1 (0.48) | MEN1KMT2AKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |