Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.67 |
| ▸ | OPRL1 | P41146 | 14/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
| ▸ | VNN1 | O95497 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | ICMT | O60725 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410993 | 0.81 | OPRM1 (1.00) | OPRM1OPRL1OPRK1VNN1ALDH1A1 | |
| SCHEMBL4345677 | 0.74 | OPRM1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3412155 | 0.72 | OPRL1 (1.00) | OPRM1OPRL1OPRK1SLC6A2SLC6A4 | |
| SCHEMBL3413521 | 0.68 | OPRL1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL4814703 | 0.68 | OPRL1 (0.53) | OPRM1OPRL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3431672 | 0.68 | OPRL1 (0.66) | OPRM1OPRL1OPRK1 | |
| SCHEMBL15761210 | 0.67 | CCR2 (0.51) | OPRM1OPRL1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17894211 | 0.67 | CES2 (0.62) | ALDH1A1 | |
| SCHEMBL4813486 | 0.66 | OPRL1 (0.60) | OPRM1OPRL1SLC6A4ALDH1A1 | |
| SCHEMBL696251 | 0.66 | AKR1C3 (0.67) | OPRM1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260021-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009118168-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | disclosed |