Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 18/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 17/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344674 | 0.79 | OPRM1 (0.62) | OPRM1OPRL1OPRK1 | |
| SCHEMBL23778868 | 0.74 | OPRM1 (0.51) | OPRM1OPRL1OPRK1 | |
| SCHEMBL10635171 | 0.74 | RAB9A (0.57) | — | |
| SCHEMBL31524305 | 0.74 | RAB9A (0.57) | — | |
| SCHEMBL23778489 | 0.73 | OPRM1 (0.41) | OPRM1OPRL1 | |
| SCHEMBL5648895 | 0.73 | LIPE (0.56) | — | |
| SCHEMBL12521051 | 0.72 | OPRM1 (0.65) | OPRM1OPRL1OPRK1 | |
| SCHEMBL3410403 | 0.72 | OPRM1 (1.00) | OPRM1OPRL1OPRK1 | |
| SCHEMBL20904051 | 0.69 | OPRM1 (0.59) | OPRM1OPRL1OPRK1 | |
| SCHEMBL28140609 | 0.69 | KMT2A (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502907-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-09-26 | — | — | EP | claimed |
| EP-2260021-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2009118168-A1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | Grünenthal GmbH (DE) | 2009-10-01 | — | — | WO | claimed |
| EP-2502907-B1 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2018-08-29 | — | — | EP | disclosed |
| EP-2518052-B1 | Substituted 4-aminocyclohexane derivatives | GRUENENTHAL GMBH (DE) | 2017-12-20 | — | — | EP | disclosed |
| EP-2260021-B1 | SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-04-23 | — | — | EP | disclosed |
| EP-2518052-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-10-31 | — | — | EP | disclosed |
| EP-2502907-A1 | Substituted 4-aminocyclohexane derivatives | Grünenthal GmbH (DE) | 2012-09-26 | — | — | EP | disclosed |