Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | GPR39 | O43194 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2092054 | 0.80 | SLC6A4 (0.56) | SLC6A4CYP11B1CYP11B2GRIN2BALDH1A1 | |
| SCHEMBL28250224 | 0.79 | MET (0.55) | SLC6A4CYP11B1CYP11B2GPR39ALDH1A1 | |
| SCHEMBL6636466 | 0.78 | SLC6A4 (0.52) | SLC6A4CYP11B1CYP11B2GPR39TDP1 | |
| SCHEMBL16770891 | 0.77 | SLC6A4 (0.58) | SLC6A4CYP11B1CYP11B2GRIN2BALDH1A1 | |
| SCHEMBL28250250 | 0.77 | SLC6A4 (0.51) | SLC6A4CYP11B1CYP11B2GPR39MAPT | |
| SCHEMBL28253155 | 0.76 | MET (0.55) | CYP11B1CYP11B2GPR39ALDH1A1KDM4E | |
| SCHEMBL508197 | 0.76 | SLC6A4 (0.49) | SLC6A4CYP11B1CYP11B2GRIN2BALDH1A1 | |
| SCHEMBL28097055 | 0.76 | LTA4H (0.59) | ALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL22621116 | 0.75 | SLC6A4 (0.51) | SLC6A4CYP11B1CYP11B2ALDH1A1MPO | |
| SCHEMBL2749763 | 0.74 | DHODH (0.58) | CYP11B1CYP11B2TDP1TLR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174293-A | 4- (imidazo [1,2-a ] pyridin-3-yl) -pyrimidine derivatives | 默克专利股份公司 | 2022-03-11 | — | — | CN | disclosed |
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |