Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.53 |
| ▸ | CCR5 | P51681 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cadaverine Tartrate SCHEMBL5927552 | 0.95 | CCR5 (0.49) | OPRM1TMEM97CCR5HTR2A | |
| SCHEMBL340360 | 0.92 | OPRM1 (0.61) | OPRM1TMEM97CCR5 | |
| Oxalic Acid SCHEMBL10322056 | 0.91 | OPRM1 (0.59) | OPRM1TMEM97CCR5 | |
| SCHEMBL341230 | 0.90 | HTR2A (0.58) | OPRM1TMEM97CCR5HTR2A | |
| Oxalic Acid SCHEMBL10322235 | 0.89 | HTR2A (0.56) | OPRM1TMEM97CCR5HTR2A | |
| SCHEMBL340417 | 0.89 | OPRM1 (0.54) | OPRM1TMEM97CCR5HTR2A | |
| SCHEMBL342375 | 0.88 | HTR2A (0.50) | OPRM1TMEM97HTR2A | |
| Oxalic Acid SCHEMBL10321753 | 0.88 | HTR2A (0.48) | OPRM1TMEM97HTR2A | |
| SCHEMBL342191 | 0.88 | HTR2A (0.55) | OPRM1TMEM97CCR5HTR2A | |
| SCHEMBL341353 | 0.87 | OPRM1 (0.53) | OPRM1TMEM97CCR5HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060205722-A1 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. | 2006-09-14 | — | — | US | claimed |
| US-20060199818-A1 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS INC. | 2006-09-07 | — | — | US | claimed |
| US-20060094758-A1 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. | 2006-05-04 | — | — | US | claimed |
| US-6936395-B2 | Image receiving sheet for fixing belt type electrophotography and image forming method using the same | FUJI PHOTO FILM CO., LTD. (JP) | 2005-08-30 | — | — | US | claimed |
| EP-1562937-A2 | N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS | Acadia Pharmaceuticals Inc. (US) | 2005-08-17 | — | — | EP | claimed |
| US-20050170155-A1 | Image recording media and image recording method | FUJI PHOTO FILM, CO., LTD (JP) | 2005-08-04 | — | — | US | claimed |
| US-20040106600-A1 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. | 2004-06-03 | — | — | US | claimed |
| US-20040043240-A1 | Image receiving sheet for fixing belt type electrophotography and image forming method using the same | FUJIFILM CORPORATION (JP) | 2004-03-04 | — | — | US | claimed |
| WO-2004000808-A2 | N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS | ACADIA PHARMACEUTICALS INC. (US) | 2003-12-31 | — | — | WO | claimed |
| US-20120122874-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR TREATING DEPRESSION | Sunovion Inc. (US) | 2012-05-17 | — | — | US | disclosed |
| US-8097625-B2 | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression | SUNOVION PHARMACEUTICALS INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-2343073-A2 | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression | Sepracor Inc. (US) | 2011-07-13 | — | — | EP | disclosed |
| US-7538222-B2 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| US-7476682-B2 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20050170155-A1 | Image recording media and image recording method | FUJI PHOTO FILM, CO., LTD (JP) | 2005-08-04 | — | — | US | disclosed |
| WO-2005060968-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION | SEPRACOR INC. (US) | 2005-07-07 | — | — | WO | disclosed |
| US-20040229044-A1 | toner receiver layers on substrate sheets having of high quality surface gloss and flexibility, for use in electrography | FUJIFILM CORPORATION (JP) | 2004-11-18 | — | — | US | disclosed |
| US-20040106600-A1 | N-substituted piperidine derivatives as serotonin receptor agents | ACADIA PHARMACEUTICALS, INC. | 2004-06-03 | — | — | US | disclosed |
| US-20040043240-A1 | Image receiving sheet for fixing belt type electrophotography and image forming method using the same | FUJIFILM CORPORATION (JP) | 2004-03-04 | — | — | US | disclosed |
| WO-2004000808-A2 | N-SUBSTITUTED PIPERIDINE DERIVATIVES AS SEROTONIN RECEPTOR AGENTS | ACADIA PHARMACEUTICALS INC. (US) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040106600-A1 | N-substituted piperidine derivatives as serotonin receptor agents | HTR1A, HTR5A, HTR1B | OPRM1 40/4885TMEM97 142/4885CCR5 1728/4885 |
| US-20060094758-A1 | N-substituted piperidine derivatives as serotonin receptor agents | HTR1A, HTR5A, HTR1B | OPRM1 40/4885TMEM97 130/4885CCR5 1560/4885 |
| US-20120122874-A1 | COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR TREATING DEPRESSION | HTR2A, HTR5A, HTR2C | OPRM1 93/4885TMEM97 171/4885CCR5 553/4885 |
| US-20060205722-A1 | N-substituted piperidine derivatives as serotonin receptor agents | HTR1A, HTR5A, HTR1B | OPRM1 40/4885TMEM97 130/4885CCR5 1560/4885 |
| US-20060199818-A1 | N-substituted piperidine derivatives as serotonin receptor agents | HTR1A, HTR5A, HTR1B | OPRM1 40/4885TMEM97 130/4885CCR5 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.