Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407979 | 0.83 | MMP8 (0.43) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL3412819 | 0.81 | RECQL (0.36) | KMT2A | |
| SCHEMBL4091310 | 0.75 | MMP8 (0.60) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL3412811 | 0.74 | MMP8 (0.51) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL19040949 | 0.65 | ALDH1A1 (0.51) | MEN1NPC1KMT2A | |
| SCHEMBL8936806 | 0.65 | ALDH1A1 (0.51) | MEN1NPC1KMT2A | |
| SCHEMBL11549783 | 0.64 | CES2 (0.52) | MEN1NPC1KMT2ACA12CA9 | |
| SCHEMBL11549787 | 0.64 | CES2 (0.52) | MEN1NPC1KMT2ACA12CA9 | |
| SCHEMBL957814 | 0.64 | MMP8 (0.66) | MMP8MEN1NPC1KMT2ACA12 | |
| SCHEMBL31339145 | 0.63 | ALDH1A1 (0.54) | MEN1NPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |