Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 9/20 | 0.55 |
| ▸ | RXRA | P19793 | 8/20 | 0.55 |
| ▸ | RXRG | P48443 | 7/20 | 0.55 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.48 |
| ▸ | BAD | Q92934 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638947 | 0.98 | RXRB (0.54) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL28739318 | 0.96 | RXRB (0.55) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL10863869 | 0.84 | ALDH1A1 (0.55) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL5659543 | 0.82 | RXRB (0.59) | RXRBRXRARXRGLMNASMN1; SMN2 | |
| SCHEMBL30150923 | 0.81 | RXRB (0.43) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL19212186 | 0.81 | RXRB (0.43) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL6662229 | 0.81 | ALDH1A1 (0.51) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL8055673 | 0.78 | AKR1B1 (0.45) | RXRBRXRARXRGAKR1B1TDP1 | |
| SCHEMBL8486125 | 0.78 | BCL2L1 (0.44) | RXRBRXRARXRGBCL2L1BAD | |
| SCHEMBL8481831 | 0.78 | ALDH1A1 (0.44) | RXRBRXRARXRGBCL2L1BAD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8487121-B2 | Chromane derivatives as TRPV3 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2013-07-16 | — | — | US | disclosed |
| US-20100311778-A1 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2010-12-09 | — | — | US | disclosed |
| EP-2254879-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009084034-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS, S. A. (CH) | 2009-07-09 | — | — | WO | disclosed |
| US-4898876-A | Benzoylpiperazine esters and a process for their production | KOWA CO., LTD. (JP) | 1990-02-06 | — | — | US | disclosed |
| EP-0098713-A2 | Benzoylpiperazine esters and a process for their production | KOWA COMPANY, LTD. (JP) | 1984-01-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100311778-A1 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | TRPV3, TRPV2, TRPV1 | RXRB 328/4885RXRA 260/4885RXRG 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.