Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6194272 | 0.79 | PNMT (0.56) | TSHRCYP1A2CYP2D6CYP2C19PNMT | |
| SCHEMBL28879956 | 0.79 | GABRA1 (0.43) | GABRA1GABRB2TSHRCYP1A2CYP2D6 | |
| SCHEMBL29566515 | 0.79 | TAAR1 (0.46) | GABRA1GABRB2TSHRCYP1A2CYP2D6 | |
| SCHEMBL166137 | 0.79 | TAAR1 (0.46) | GABRA1GABRB2TSHRCYP1A2CYP2D6 | |
| SCHEMBL31152963 | 0.77 | GABRA1 (0.56) | GABRA1GABRB2TSHRCYP1A2CYP2D6 | |
| SCHEMBL1759301 | 0.76 | PARP1 (0.40) | GABRA1GABRB2TSHRPNMTTAAR1 | |
| SCHEMBL1701340 | 0.76 | GABRA1 (0.40) | GABRA1GABRB2TSHRCYP1A2CYP2D6 | |
| SCHEMBL430886 | 0.76 | CA2 (0.43) | GABRA1GABRB2LMNAALDH1A1MEN1 | |
| SCHEMBL15994927 | 0.76 | CYP1A2 (0.38) | CYP1A2CYP2D6CYP2C19LMNAPNMT | |
| SCHEMBL1849111 | 0.76 | GABRA1 (0.35) | GABRA1GABRB2TSHRTAAR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262803-A1 | POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[L,2-A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009144391-A1 | POLYSUBSTITUTED DERIVATIVES OF 2-ARYL-6-PHENYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | WO | disclosed |