Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.30 |
| ▸ | AKT2 | P31751 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409188 | 0.76 | PTGDR2 (0.48) | PTGDR2 | |
| SCHEMBL3952944 | 0.70 | FFAR1 (0.43) | MAPTPTGDR2FFAR1FFAR4SMN1; SMN2 | |
| SCHEMBL3426364 | 0.67 | KMT2A (0.38) | S1PR5PTGDR2KMT2AALDH1A1CD274 | |
| SCHEMBL149825 | 0.62 | AKR1C3 (0.41) | PTGDR2KMT2ATRPV1PTGS1PTGS2 | |
| SCHEMBL9747690 | 0.61 | ABCB11 (0.45) | PTGS1PTGS2 | |
| SCHEMBL11758496 | 0.60 | AGBL2 (0.55) | PTGDR2HPGD | |
| SCHEMBL8109524 | 0.58 | HAO1 (0.54) | DRD2DRD4SIGMAR1HPGDSMN1; SMN2 | |
| SCHEMBL10711137 | 0.57 | PTGS1 (0.40) | PTGDR2HPGDSUCNR1PTGS1PTGS2 | |
| SCHEMBL3745897 | 0.57 | KEAP1 (0.47) | MAPTPTGDR2DRD2MEN1KMT2A | |
| SCHEMBL11703057 | 0.56 | FFAR1 (0.42) | MEN1KMT2AFFAR1FFAR4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | claimed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | claimed |