Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 9/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 9/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4646472 | 0.91 | TP53 (0.36) | ADRA1AADRA1BKDM4EALDH1A1POLB | |
| SCHEMBL4643540 | 0.89 | POLB (0.38) | ADRA1AADRA1BKDM4EALDH1A1POLB | |
| SCHEMBL4648112 | 0.86 | SCN1A (0.39) | ADRA1AADRA1BKDM4EALDH1A1POLB | |
| SCHEMBL4648354 | 0.85 | POLB (0.43) | KDM4EALDH1A1POLBP2RX7MEN1 | |
| SCHEMBL3416630 | 0.83 | SOS1 (0.35) | ADRA1AADRA1BALDH1A1POLBSCN1A | |
| SCHEMBL4648508 | 0.78 | ALDH1A1 (0.40) | ALDH1A1POLBP2RX7MEN1KMT2A | |
| SCHEMBL4647815 | 0.78 | P2RX7 (0.43) | KDM4EALDH1A1POLBP2RX7TP53 | |
| SCHEMBL3378843 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1POLBP2RX7MEN1 | |
| SCHEMBL3381143 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1POLBP2RX7MEN1 | |
| SCHEMBL3378836 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1POLBP2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |