Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | SCN1A | P35498 | 6/20 | 0.34 |
| ▸ | SCN8A | Q9UQD0 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409569 | 0.91 | ADRA1A (0.37) | TP53ADRA1AADRA1BSCN1ASCN8A | |
| SCHEMBL4648354 | 0.88 | POLB (0.43) | POLBKDM4EALDH1A1P2RX7MEN1 | |
| SCHEMBL4643540 | 0.87 | POLB (0.38) | ADRA1AADRA1BSCN1ASCN8APOLB | |
| SCHEMBL4648112 | 0.84 | SCN1A (0.39) | ADRA1AADRA1BSCN1ASCN8APOLB | |
| SCHEMBL4646898 | 0.84 | POLB (0.36) | SCN1ASCN8APOLBSLC2A1SCN5A | |
| SCHEMBL4648701 | 0.82 | P2RX7 (0.45) | POLBALDH1A1P2RX7 | |
| SCHEMBL4646463 | 0.78 | HDAC3 (0.44) | ALDH1A1P2RX7 | |
| SCHEMBL4647815 | 0.76 | P2RX7 (0.43) | TP53POLBKDM4EALDH1A1P2RX7 | |
| SCHEMBL3378843 | 0.75 | KDM4E (0.46) | POLBKDM4EALDH1A1P2RX7MEN1 | |
| SCHEMBL3381143 | 0.75 | KDM4E (0.46) | POLBKDM4EALDH1A1P2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2008-03-19 | — | — | EP | claimed |
| WO-2006136924-A1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-12-28 | — | — | WO | claimed |