Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT2 | O75908 | 1/20 | 0.39 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414055 | 0.79 | SOAT1 (0.48) | SOAT2ACAT1SOAT1KMT2AMEN1 | |
| SCHEMBL3413997 | 0.78 | SOAT1 (0.49) | SOAT2ACAT1SOAT1KMT2AMEN1 | |
| SCHEMBL3409925 | 0.73 | KMT2A (0.36) | NLRP3KMT2AMEN1TDP1LMNA | |
| SCHEMBL13083184 | 0.72 | SOAT1 (0.41) | SOAT2ACAT1SOAT1 | |
| SCHEMBL10189418 | 0.71 | SOAT2 (0.48) | SOAT2SOAT1NLRP3KMT2ALMNA | |
| SCHEMBL13083298 | 0.71 | SOAT1 (0.42) | SOAT2ACAT1SOAT1 | |
| SCHEMBL3410909 | 0.70 | NLRP3 (0.46) | NLRP3 | |
| SCHEMBL3412551 | 0.67 | SOAT1 (0.52) | SOAT2ACAT1SOAT1NLRP3KMT2A | |
| SCHEMBL854439 | 0.66 | SOAT2 (0.47) | SOAT2ACAT1SOAT1NLRP3SMN1; SMN2 | |
| SCHEMBL3410552 | 0.65 | SOAT1 (0.53) | SOAT2ACAT1SOAT1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200979-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009030752-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | disclosed |