Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.45 |
| ▸ | IKBKB | O14920 | 2/20 | 0.45 |
| ▸ | CHUK | O15111 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413279 | 0.88 | CDK2 (0.46) | CDK2CCNA2CCNA1IKBKBCHUK | |
| SCHEMBL3406069 | 0.83 | PTGS2 (0.40) | CDK2SYK | |
| SCHEMBL3406820 | 0.79 | L3MBTL1 (0.39) | SYK | |
| SCHEMBL4102506 | 0.77 | CDK2 (0.49) | CDK2CCNA2CCNA1IKBKBCHUK | |
| SCHEMBL3411020 | 0.76 | SYK (0.41) | SYK | |
| SCHEMBL3409757 | 0.76 | CDK9 (0.47) | CDK2CCNA2GSK3BCDK4PIK3CA | |
| SCHEMBL3407305 | 0.75 | PIK3CA (0.61) | CDK2IKBKBCLK1DYRK1ACLK4 | |
| SCHEMBL3408739 | 0.75 | PTGS2 (0.41) | CDK2IKBKBCHUKGSK3BSYK | |
| SCHEMBL3408631 | 0.74 | PIK3CG (0.47) | CDK2CCNA2CCNA1IKBKBCHUK | |
| SCHEMBL3412794 | 0.74 | SYK (0.39) | CDK2CCNA2CCNA1GSK3BCLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |