Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406069 | 0.92 | PTGS2 (0.40) | PTGS2SYKCDK2MCHR1TP53 | |
| SCHEMBL3412354 | 0.90 | PTGS2 (0.39) | PTGS2SYKTP53MAPTPSEN1 | |
| SCHEMBL3409722 | 0.79 | PIK3CA (0.41) | PTGS2CDK2TP53MAPTPSEN1 | |
| SCHEMBL3408075 | 0.78 | PSEN1 (0.47) | PTGS2SYKMCHR1PSEN1PSEN2 | |
| SCHEMBL3405215 | 0.77 | KCNH2 (0.37) | PTGS2CDK2 | |
| SCHEMBL3409955 | 0.75 | CDK2 (0.48) | SYKCDK2IKBKBCHUKGSK3B | |
| SCHEMBL3407100 | 0.74 | MAPT (0.48) | PTGS2CDK2TP53MAPT | |
| SCHEMBL3413279 | 0.74 | CDK2 (0.46) | CDK2IKBKBCHUKGSK3B | |
| SCHEMBL3408556 | 0.74 | PLK1 (0.36) | PTGS2SYKMAPTPSEN1PSEN2 | |
| SCHEMBL3410261 | 0.74 | SYK (0.37) | SYKTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | claimed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | claimed |
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |