Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413340 | 0.87 | CYP1A2 (0.62) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL7720766 | 0.82 | NPC1 (0.56) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL7720768 | 0.82 | NPC1 (0.56) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL20300432 | 0.80 | HDAC3 (0.47) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL11217696 | 0.79 | HSD17B3 (0.55) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL20300318 | 0.76 | HDAC3 (0.47) | LMNANPC1RAB9ACHRM1HTR2A | |
| SCHEMBL28375640 | 0.76 | TRPM8 (0.49) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL5677328 | 0.74 | RAB9A (0.58) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL5677325 | 0.74 | RAB9A (0.58) | LMNAHTTNPC1ALDH1A1MAPT | |
| SCHEMBL453913 | 0.73 | IDO1 (0.48) | LMNAHTTNPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |