Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 6/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637448 | 0.91 | NPC1 (0.46) | MEN1KMT2ACREBBPNR1H4NPC1 | |
| SCHEMBL2638043 | 0.90 | MAPK10 (0.45) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL2637918 | 0.89 | KMT2A (0.41) | MEN1KMT2AEGFRSRCALDH1A1 | |
| SCHEMBL2637204 | 0.86 | NPC1 (0.43) | MEN1KMT2ANR1H4EGFRALDH1A1 | |
| SCHEMBL2637207 | 0.83 | CNR2 (0.45) | MEN1KMT2AEGFRALDH1A1NPC1 | |
| SCHEMBL2637520 | 0.82 | DHODH (0.45) | MEN1KMT2AEGFRSRCNPC1 | |
| SCHEMBL2637246 | 0.81 | MAPK10 (0.41) | MEN1KMT2AEGFRRAB9A | |
| SCHEMBL2637350 | 0.81 | ERCC1 (0.48) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL2640983 | 0.79 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL2637908 | 0.78 | NPC1 (0.45) | MEN1KMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | claimed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | claimed |
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |