Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ACR | P10323 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12642676 | 0.92 | TGFBR1 (0.39) | TGFBR1CYP2D6CYP2C19RXFP1MEN1 | |
| SCHEMBL16097 | 0.92 | TGFBR1 (0.39) | TGFBR1CYP2D6CYP2C19RXFP1MEN1 | |
| SCHEMBL4960192 | 0.90 | TGFBR1 (0.38) | TGFBR1CYP2D6CYP2C19RXFP1MEN1 | |
| Propylene Glycol SCHEMBL28248623 | 0.86 | TGFBR1 (0.44) | TGFBR1CYP2D6CYP2C19RXFP1ALDH1A1 | |
| Glycine SCHEMBL1564191 | 0.85 | TGFBR1 (0.37) | TGFBR1CYP2D6CYP2C19RXFP1MEN1 | |
| Lactic Acid SCHEMBL545470 | 0.84 | TGFBR1 (0.40) | TGFBR1TP53CYP2D6CYP2C19RXFP1 | |
| Lactic Acid SCHEMBL544712 | 0.82 | TGFBR1 (0.48) | TGFBR1TP53CYP2D6CYP2C19RXFP1 | |
| Lactic Acid SCHEMBL544967 | 0.81 | TGFBR1 (0.38) | TGFBR1TP53 | |
| Acrylamide SCHEMBL21723567 | 0.80 | TSHR (0.38) | TGFBR1RXFP1ALDH1A1TSHR | |
| SCHEMBL1682417 | 0.80 | TGFBR1 (0.46) | TGFBR1CYP2D6CYP2C19RXFP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10406079-B2 | Structures containing thermo-sensitive gels | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2019-09-10 | — | — | US | claimed |
| US-20180338891-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY CLARK CO (US) | 2018-11-29 | — | — | US | claimed |
| WO-2017095366-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2017-06-08 | — | — | WO | claimed |
| US-20040247670-A1 | Temperature sensitive polymers | CRISTAL DELIVERY B.V. (NL) | 2004-12-09 | — | — | US | claimed |
| EP-3191534-B1 | AMPHIPHILIC BLOCK COPOLYMERS FOR DELIVERY OF ACTIVE AGENTS | RWTH AACHEN (DE) | 2025-10-01 | — | — | EP | disclosed |
| US-12251378-B2 | Long-acting local anesthetic formulation | UNIVERSITY OF CONNECTICUT (US) | 2025-03-18 | — | — | US | disclosed |
| US-12138274-B2 | Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2024-11-12 | — | — | US | disclosed |
| US-10406079-B2 | Structures containing thermo-sensitive gels | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2019-09-10 | — | — | US | disclosed |
| US-20180338891-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY CLARK CO (US) | 2018-11-29 | — | — | US | disclosed |
| WO-2017095366-A1 | STRUCTURES CONTAINING THERMO-SENSITIVE GELS | KIMBERLY-CLARK WORLDWIDE, INC. (US) | 2017-06-08 | — | — | WO | disclosed |
| US-8110220-B2 | Temperature sensitive polymers | UNIVERSITEIT UTRECHT (NL) | 2012-02-07 | — | — | US | disclosed |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2012-01-19 | — | — | US | disclosed |
| EP-2034028-A1 | Non-homogeneous modification of liquids | Koninklijke Philips Electronics N.V. (NL) | 2009-03-11 | — | — | EP | disclosed |
| US-7425581-B2 | Temperature sensitive polymers | UNIVERSITEIT UTRECHT | 2008-09-16 | — | — | US | disclosed |
| US-20080050435-A1 | Temperature Sensitive Polymers | CRISTAL DELIVERY B.V. (NL) | 2008-02-28 | — | — | US | disclosed |
| EP-1776400-A2 | TEMPERATURE SENSITIVE POLYMERS | Universiteit van Utrecht (NL) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005087825-A2 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2005-09-22 | — | — | WO | disclosed |
| US-20040247670-A1 | Temperature sensitive polymers | CRISTAL DELIVERY B.V. (NL) | 2004-12-09 | — | — | US | disclosed |
| EP-1214361-A1 | TEMPERATURE SENSITIVE POLYMERS | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001009198-A1 | TEMPERATURE SENSITIVE POLYMERS | STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN (NL) | 2001-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080050435-A1 | Temperature Sensitive Polymers | LCT, LDHB, LDHA | TGFBR1 4008/4885TP53 1460/4885CYP2D6 2049/4885 |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | LCT, LDHA, LDHB | TGFBR1 4012/4885TP53 1519/4885CYP2D6 1597/4885 |
| US-20040247670-A1 | Temperature sensitive polymers | LCT, LDHA, LDHB | TGFBR1 4267/4885TP53 2166/4885CYP2D6 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.