Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.37 |
| ▸ | PLK1 | P53350 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | STK17B | O94768 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413396 | 0.86 | PIK3CA (0.39) | KDRSTK17APLK1BRD4PSEN1 | |
| SCHEMBL3410440 | 0.83 | NPC1 (0.36) | KDRSTK17APLK1PSEN1PSEN2 | |
| SCHEMBL3410488 | 0.79 | BRD4 (0.40) | KDRPLK1BRD4JAK2CYP3A4 | |
| SCHEMBL3410455 | 0.78 | MEN1 (0.42) | KDRPLK1PSEN1PSEN2APH1B | |
| SCHEMBL3406186 | 0.76 | KDR (0.42) | KDRSTK17APLK1BRD4EGFR | |
| SCHEMBL3407305 | 0.75 | PIK3CA (0.61) | PLK1EGFRJAK2CDK2PIK3CA | |
| SCHEMBL3412792 | 0.75 | KDR (0.48) | KDRPLK1CDK2CDK9 | |
| SCHEMBL3410224 | 0.75 | TP53 (0.43) | KDRSTK17APLK1EGFRCYP17A1 | |
| SCHEMBL3405288 | 0.74 | KDR (0.41) | KDRPLK1BRD4JAK2CDK2 | |
| SCHEMBL3406073 | 0.74 | PIK3CA (0.41) | KDRSTK17APLK1BRD4STK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |