Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410440 | 0.89 | NPC1 (0.36) | KDRPLK1STK17APSEN1PSEN2 | |
| SCHEMBL3408813 | 0.88 | SYK (0.35) | PIK3CAPIK3CBPIK3CGCDK2CCNT1 | |
| SCHEMBL3412452 | 0.87 | EGFR (0.40) | PIK3CAPIK3CBPIK3CGJAK2EGFR | |
| SCHEMBL3410239 | 0.86 | KDR (0.38) | PIK3CAPIK3CBPIK3CGJAK2EGFR | |
| SCHEMBL3409536 | 0.83 | RET (0.40) | CDK2CCNT1CDK9KDRBRD4 | |
| SCHEMBL3410466 | 0.82 | PSEN1 (0.43) | PIK3CAPIK3CBPIK3CGJAK2EGFR | |
| SCHEMBL3407305 | 0.81 | PIK3CA (0.61) | PIK3CAPIK3CBPIK3CGJAK2EGFR | |
| SCHEMBL3411154 | 0.81 | PSEN1 (0.43) | CDK2CCNT1CDK9RETAURKA | |
| SCHEMBL3408509 | 0.80 | CDK9 (0.40) | CDK2CCNT1CDK9KDRBRD4 | |
| SCHEMBL3406106 | 0.79 | IGF1R (0.41) | CDK2CCNT1CDK9KDRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |