Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | AGPAT2 | O15120 | 4/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413396 | 0.89 | PIK3CA (0.39) | NPC1RAB9APLK1PSEN1PSEN2 | |
| SCHEMBL3410239 | 0.83 | KDR (0.38) | NPC1RAB9APLK1PSEN1PSEN2 | |
| SCHEMBL3407955 | 0.81 | NPC1 (0.51) | NPC1RAB9AKCNH2MAPTGAA | |
| SCHEMBL3406232 | 0.81 | NPC1 (0.41) | NPC1RAB9AKCNH2PSEN1PSEN2 | |
| SCHEMBL3413207 | 0.78 | PSEN1 (0.52) | NPC1RAB9AAGPAT2KCNH2PSEN1 | |
| SCHEMBL3408338 | 0.77 | NPC1 (0.40) | NPC1RAB9APLK1KCNH2PSEN1 | |
| SCHEMBL3408813 | 0.77 | SYK (0.35) | PLK1KDRSTK17AP2RX3 | |
| SCHEMBL3412730 | 0.76 | PIK3CA (0.40) | NPC1RAB9AAGPAT2KCNH2PSEN1 | |
| SCHEMBL3410260 | 0.76 | NPC1 (0.53) | NPC1RAB9AKCNH2MAPTGAA | |
| SCHEMBL3412452 | 0.76 | EGFR (0.40) | SMN1; SMN2KDRSTK17A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |